李春富¹  张有林¹  李兴亮¹  杨亚明¹  刘慧¹  舒文谊²  张翔³  指导者：车立刚

1．云南省疟疾防治研究所  思茅665000   2．景洪县医院      3．勐腊县医院

全文发表于《实用寄生虫病杂志》1994年第2卷第3期31-33页

 

提要：磷酸咯萘啶800g（基质）与复方磺胺多辛2片,伯喹45mg（基质）伍用，在抗氯喹恶性疟流行区治疗恶性疟42例,平均退热时间39.0±17.3h；平均原虫无性体转阴时间41.5±13.6h。服药后48h疟原虫无性体下降率为97.6－100％，28天内复燃率为10.3％（3／29）；治后5天内配子体清除率达87.5％。与5年前的疗效相似。显示该方案并不随恶性疟原虫对咯萘啶的敏感下降而下降,当地临床观察证实恶性疟原虫对复方磺胺多辛、乙胺嘧啶的抗性率达41.7％。

关键词：磷酸咯萘啶，抗药性疟疾，恶性疟原虫

 

COMBINATION OF PYRONARIDINE, SULFADOXINE, PYRIMETHAMINE, AND PRIMAQUINE ON FALCIPARUM MALARIA IN MULTI-DRUG RESISTANT AREAS

Li Chunfu¹, Zhang Youlin¹, Li Xingliang¹, Yang Yaming¹

Liu Hui¹, Shu Wenyi², Zhang Xiang³

Instructor： Che Ligang

1. Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

2. The people´s Hospital of Jinghong County

3. The people´s Hospital of Mengla County

 

ABSTACT：In 1993,42 malaria cases from southern Yunnan endemic areas with P. falciparum resistant to chloroquine, amodiaquine,piperaquine and sulfadoxine／pyrinethamine were treated with combination of pyronaridine(800mg), sulfadoxine(1000mg), pyrimethamine (50mg) and primaquine (45mg) in 2 days.The results.average defervescent time 39.0±17.3h，mean clearance time of asexual parasite 41.5±13.6h，recrudescence rate 10.3%(3/29) 28 days after treatment, and gametocyte clearance rate 87.5% 5 days after treatment showed no difference as compared with the effect of combintion of pyronaridine (800mg), sulfadoxine(1000mg) and pyrimethamine (50mg) in 1987, though the sensitivity of P. falciparum was decreascd to pyronaridine and sulfadoxine and sulfadoxine / pyrimethamine.

Key words：Pyronaridine, multi-drug resistant,falciparum malaria

 

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