杨亚明^１  杨恒林^１  董  莹^１　廖明铮^２

1.云南省疟疾防治研究所  思茅 665000   2. 云南省瑞丽市防疫站  瑞丽 678000

全文发表于《实用寄生虫病杂志》1994年第2卷第3期23-25页

 

提要：应用体外微量法检测恶性疟原虫对氯喹、氨酚喹、青蒿琥酯、还原青蒿琥酯、蒿乙醚及咯萘啶的抗性率，我国境内的分别是95.7 %(22/23)、88.9％（8／9）、16.5％(4/24)、22.2％（2／9）、11.1％（1/9）、20.8％（5/24）；半数抑制量（ID₅₀）分别为176、72、6、13、118、16nmol/L；ID₉₅依次为830、512、34、80、650、88nmol/L。缅甸境内的分别为100％（29／29）、83.3％（5／6）、13.8％（4／29）、16.7％（1／6）、21.4％（6／28）；ID₅₀分别为240、52、6、14、120、18nmol／L；ID₉₅为1408、384、34、80、650、96nmol/L。境内、外恶性疟原虫对奎宁均敏感，ID₅₀分别为608、470nmol/L；ID₉₅为2560，1690nmol/L。证实该地区恶性疟原虫对氯喹普遍存在高度抗性，且缅甸高于我国；对氨酚喹亦普遍产生抗性；对青蒿琥酯，还原青蒿素、蒿乙醚、咯萘啶有少数疟原虫产生低度抗生。抗氯喹恶性疟原虫对青蒿琥酯，还原青蒿素、蒿乙醚和咯萘啶无交叉抗性。抗青蒿琥酯恶性疟原虫对咯萘啶有交叉抗性。

关键词：恶性疟原虫，抗疟药，敏感性，体外测定

 

IN VITRO SENSITIVITY OF PLASMODIUM FALCIPARUM TO SEVEN ANTIMALARIA DRUGS IN CHINA-BURMA BORDER AREA

Yang Yaming，Yang Henglin，Dong Ying

Institute of Malaria Prevention and Treatment of Yunnan Province，Simao   665000

Liao Mingzheng

Sanitary and Anti-epidemic Station of Ruili

ABSTRACT. During 1991-1993, the sensitivity of P. falciparum to chloroquine, amodiaquine, artesunate, dihydroartemisinine, arteether, pyronaridine was detemined with in vitro microtechnique in Ruili border area. The resistance rates in inter-China were 95.7 %(22/23)、88.9％（8／9）、16.5％(4/24)、22.2％（2／9）、11.1％（1/9）、20.8％（5/24）and ID₅₀ were176, 72, 6,13, 118,16 nmol/L; and ID₉₅  were 830、512、34、80、650、88nmol/L respectively. The resistance rates in inter-Burma were in order 100%(29/29), 83.3％（5／6）、13.8％（4／29）、16.7％（1／6）、21.4％（6／28）；ID₅₀  240、52、6、14、120、18nmol／L；ID₉₅  were 1408、384、34、80、650、96nmol/L. Wherever P. falciparum was from Burma or China,it revealed sensitive to quinine. The ID₅₀  were 608 and 470 nmol/L while ID₉₅ 2560 and 1690nmol/L. The results showed that high resistance to chloroquine and amodiaquine had commonly been produced in the area; and resistance in Burma was higher than in China. A few p.falciparum also produced low resistance to artesunate, dihydroartemisinine, arteether, and pyronaridine.

Chloroquine-resistant P. falciparum showed no cross-resistance to artesunate, arteether, dihydroartemisinine, and pyronaridine. But artesunate-resistant p.falciparum exhibited cross-resistance to pyronaridine.

Key words: Plasmodium falciparum, sensitivity, antimalaria drugs, in vitro microtechnique

 

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