车立刚  张有林  李兴亮  杨亚明  李春富  刘慧   云南省疟疾防治研究所  （思茅665000）

全文发表于《中国寄生虫防治杂志》1994年第7卷第4期259-261页

 

提要：苯芴醇1600mg与青蒿琥酯400mg3d分服治疗抗药性恶性疟56例，退热时间33.3±14.5h，原虫无性体转阴时间34.1±9.7h，28d根治率100%，无明显不良反应，对配子体形成和原虫孢子增殖有一定抑制效果，疗程和剂量均低于单方组，疗效也较单方组为优，是治疗抗药性恶性疟的适宜方案。

关键词：抗药性，恶性疟，苯芴醇，青蒿琥酯

EFFICACY OF BENFLUMETOLUM / ARTESUNATE AGAINST THE DRUG-RESISTANT FALCIPARUM MALARIA

Che Li-Gang, Zhang You-Lin, Li Xing-Liang, Yang Ya-Ming, Li Chun-Fu, Liu Hui

Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

 

Abstract：Fifty-six patients suffering from drug-resistant falciparum malaria were treated with 1600mg benflumetolum and 400mg artesunate for 3 days. As a result, fever clearance time was 33.3、14.5h, asexual parasite clearance time 43.1±9.7h and radical cure rate was 100% during a 28-day-follow-up. No side effect was observed. This treatment can inhibit gametocytogenesis and sporogony to some extent. The course of this treatment was shorter than that of single benfoumetolam. Its dosage was less than that of the later one and its efficacy was much higher, It is a suitable method for treating the drug resistant falciparum malaria.

Key words：Resistance, falciparum malaria, benflumetolum, artesunate

 

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