朱德福（云南省疟疾防治研究所  思茅  665000）

全文发表于《中国寄生虫病防治杂志》1994年第7卷第2期84-87页

 

提要：云南省是我国恶性疟主要流行区。历史上分布于北伟25°以南的高、中疟区65个县（市），海拨1200m以下的地区。1980年全省恶性疟发病数已控制至1019例，仅占当年疟疾疫情报告数的3.16％。由于流动人口的剧增，国外传染源的输入，抗氯喹株恶性疟的扩散，1992年恶性疟病例上升至5379例，比1980年增加4.28倍，已占全省疟疾疫情报告数的30.56％，报告恶性疟的县（市）数已达74个。几年来通过恶性原虫对抗疟药敏感性监测，结果表明氯喹及哌喹抗性程度仍然严重。本文概述了云南省恶性疟流行状况及抗氯喹恶性疟的分布、发展及治疗方案。

关键词：恶性疟，暴发流行，抗氯喹恶性疟，咯萘啶

 

PREVALENT OUTLINE OF FALCIPARUM MALARIA AND THE RESISTANCE OF P. FALCIPARUM TO CHLOROQUINE IN YUNNAN PROVINCE

Zhu De-fu

Institute of Malaria prevention and Treatment of Yunnan Province  (Simao 665000)

 

Abstract：Yunnan Province is one of the major falciparum malaria areas in China. In recent years, the increase of migrating populatinon has brought about a number of cases of imported falci-parum malaria, thus widening the distribution of chroloquine－resistant falciparum malaria, 5379 cases of falciparum nalaria were detected in 1992, 4.28 times as many as that in 1980,accounting for 30.99% of the total number of malaria cases in the province and covering 74 counties. The monitoring over the sensitivity of falciparum parasites to antimalaria drugs showed that falciparum malaria was still highly resistant to both chroloquine and piperaquine. The status of falciparum malaria and the distribution of chroloquine－resistant falciparum malaria, its prevalence trend and therapy were analysed in this paper.

Key words：Falciparum malalria, outbreaks, chloroquine-resistant, pyronaridine

 

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