杨恒林¹  刘德全²  董  莹¹ 杨品芳¹  刘瑞君²  詹斌²  张春勇²

1．云南省疟疾防治研究所 思茅 665000   2．中国预防医学科学院寄生虫病研究所 上海 200025

全文发表于《中国寄生虫学与寄生虫病杂》1995年13卷2期111-113页

 

提要  ：1992年应用体外微量法在中老边境测得我国境内恶性疟原虫对氯喹、哌喹、青蒿琥酯、蒿甲醚、蒿乙醚、还原青蒿素及咯萘啶抗性率，分别为97.0％、96.4％、12.1％、16.0％、6.2％、12.5％、34.5％；半数抑制量（ID₅₀）依次为119.0、320 、7.2、295、0、74.4、5.4及31.9 nmol/L。老挝境内恶性疟原虫分离株对氯喹、派喹及咯萘啶的抗性率分别为9／10、8／10及1／5；ID₅₀依次为114.0、166.9及16.4 nmol/L；对青蒿琥酯、蒿甲醚、高乙醚及还原青蒿素均敏感，ID₅₀分别为5.0、91.6、56.7及4.4nmol／L。结果提示境内外恶性疟原虫株对氯喹的抗性程度相似，但对哌喹抗性程度境外明显低于境内。对青蒿琥酯、蒿甲醚、蒿乙醚及还原青蒿素的敏感性境外明显高于境内。

关键词：恶性疟原虫，体外测定，氯喹，哌喹，青蒿素类药物，咯萘啶

 

SENSITIVITY OF PLASMODIUM FALCIPARUM TO SEVEN ANTIMALARIALS IN CHINA-LAOS BORDER

Yang Henglin¹,Liu Dequan²,Dong Ying¹,Yang Pinfang¹,Liu Ruijun²,

Zhang Bin²,Zhang Chunyong²

1 Institute of Malaria Prevention and Treatment of Yunnan Province,Simao 665000

2 Institute of Parasitic Diseases,Chinese Academy of Preventive Medicine,Shanghai 200025

 

ABSTRACT.The sensitivity of P. falciparum to chloroquisne(CHL), piperaquine(PIP), artesunate(ATS),dihydroartemisinine(DAT), artemether

(ATM), arteethe(ATE) and pyronaridine(PRN)were assayed by in vitro microtechnique in China-Laos border in 1992. The resistance rates of isolates from the south of Yunnan of China in the border were 97.0％，96.4％，12.5％，16.0％，6.3％ and 34.5％，respectively;ID₅₀ were119.0，320，7.2，5.4,295.0，74.4，and 31.9 nmol/L，ID₉₅ were 625.0, 2426.0，42.2，36.6，767.0 ,371.1 and 325.2nmol/L. The resistance rates of isolates from the north border of  Laos were in order 9／10，8／10，1／5 to CHL，PIP，PRN，ID₅₀ were 114.0，166.9，16.4 nmol/L，ID₉₅ were 570.0，631.1 and 101.7 nmol/L. All the isolates from Laos were sensitive to ATS,DAT，ATM and ATE. ID₅₀ were 5.0，4.4，91.6，and 56.7nmol/L，ID₉₅ were 23.4，11.1，3276.1 and 223.9 nmol/L，respectively.

The results indicate that P. falciparum in the border was highly resistant to CHL and PIP, while most of the isolates were susceptible to the other 5 of the above-mentioned drugs. A comparison between the isolates from China and Laos showed that there was no significant difference in resistance degree to CHL but the sensitivity of isolates from China to other 6 drugs was lower than those from Laos.

Key words：P. falciparum, in vitro assay, chloroquine,piperaquine,Artemisinine derivatives, pyronaridine

 

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