李华宪¹  杨柏林²  胡惠仙¹  汪文仁¹  王文俊²  李兴亮¹王  翔¹  李崇珍¹  黄国珍¹

1．云南省疟疾防治研究所 思茅 665000  2．中国预防医学科学寄生虫病研究所 上海 200025

全文发表于《中国寄生虫学与寄生虫病杂志》1994年12卷2期119-121页

提要：滇南的实验结果显示，人工接种当地间日疟原虫子孢子后，经短潜伏期发病的38名志愿者，首次见虫时间为8－13d，首次见虫和临床初发时的原虫密度分别为0.2－1.6和0.6－4040个／ul。造成如此明显差异的原因，似与虫现期和临床初发间的时间距离密切有关，表现为感染后临床初发的时间越早，多数病例首次见虫时的原虫密度越低，反之则高。文中讨论了这一问题在病原生物学和流行病学上的重要性。

关键词：间日疟原虫，疟原虫出现前期，潜伏期

OBSERVATION ON PARASITE DENSITY IN THE EARLY STAGE OF VIVAX MALARIA

Li Huaxian, Yang Bailin, Hu Huixian, Wang Wenren, Wang Wenjun

Li Xianglian, Li Chongzhen, Huang Guozhen

1 Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

2 Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai  200025

ABSTRACT. Thirty-eight cases  were artificially infected with local Plasmodium vivax sporozoites and experienced onsets of acute attacks after a short incubation period.The parasite densities upon the patent of malaria parasites in the peripheral blood and the primary clinical onset were 0.2－1.6 and 0.6 －0.6－4040/ul，respectively. Such significant difference in parasitaemia level seems to be closely related to the interval between the initial parasitaemia and the first onset, as indicated by the fact that for the majority of cases, the earlier the appearance of clinical attack after sporozoite inoculation, the lower the parasite density at the beginning of the patent period, while primary onsets of later occurrence, in those with higher initial parasitemia. The biological and epidemiological significance of the evidence was discussed.

Key words：Plasmodium vivax, prepatent period, incubation period

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