车立刚  李兴亮  杨亚明  张有林  李春富  刘慧  张有林

云南省疟疾防治研究所  思茅  665000

全文发表于《实用寄生虫病杂志》1993年第1卷第1期31-33页

 

提要：青蒿琥酯600mg与伯喹90mg伍用，治疗抗药性恶性疟43例，退热时间26.9±19.5h，原虫无性体转阴时间33.8±10.4h，28d复燃率6.5％，对配子体形成和清除有明显效果，副反应少，但疗程长，对G－6－PD缺陷者不宜。与Fansimef相比，在退热速度、对配子体作用、副反应方面优于后者。

关键词：抗药性恶性疟，青蒿琥酯，复方甲氟喹

 

EFFICACY OF ARTESUNATE/PRIMAQUINE AGAINST DRUG-RESISTANT FALCIPARUM MALARIA

Che Ligang, Li Xingliang, Yang Yaming, Zhang Youlin

 Li Chunfu, Liu Hui, Shu Wenyi

Institute of Malaria Prevention and Treatment of Yunnan Province, Simao  665000

 

ABSTRACT. Forty-three cases suffered from drug-resistant falciparum malaria were treated with artesunate 600mg and primaquine 90mg.Fever clearance time was 26.9±19.5h, asexual parasite clearance time 33.8±10.4h, and recrudescence rate 6.5% during 28-day´s following-up. The regimen showed good effect on inhibiting gametocytogenesis and clearing gametocytes. It revealed few side-effect but long course of treatment. It is not suitable for treating cases lacking of G-6-PD. Compared with fansimef, it is better on speed of fever clearance, action on gametocytes and side-effect.

Key words: Drug-tesistant, falciparum, malaria, artesunate, mefloquine co

 

注：转载请注明出处、谢谢合作