车立刚  杨恒林  杨品芳  曾家植  张 强 舒文谊 郭志忠 杨 景

1．  腊县人民医院  666300  2．景洪县人民医院  666150

3．打洛县打洛镇卫生院  666212

全文发表于《新药与临床》1991年10卷1期47－48页

 

提要：恶性疟疾现症病人103例，其中83例（男56例，女27例；年龄25±14yr）用蒿甲醚80mg,im, qd(首剂加倍)5d为一个疗程；儿童用量递减；其中有脑型恶性疟1例，并发黑尿热者3例；临床治愈率100％，退热时间为37±24h，平均疟原虫无性体转阴时间为47±20h，35d内的复燃率达13％。另外20例用青蒿琥酯60mg,iv, qd（首剂加倍）4d为一个疗程，疗效与蒿甲醚相似。

关键词：恶性疟原虫，蒿甲醚／治疗应用，青蒿琥酯／治疗应用

 

ARTEMETHER TREATMENT OF FALCIPARUM MALARIA IN 83 PATIENTS

CHE Li-Gang, YANG Heng-Lin, YANG Pin-Fang

Institute of Malaria Control and Research, Simao 665000

AENG Jia-Zhi, ZHANG Qiang,   The People´s Hospital of Mengla, Mengla  666300

SHU Wen-Yi, GUO Zhi-Zhong    The People´s Hospital of Jinghong, Jinghong  666150

YANG Jing    The People´s Hospital of Daluo, Daluo  666212

 

ABSTRACT. Artemether and artesunate are two new antimalarals.In treating 83 patients of acute falciparum malara(M56，F27；age25±14yr)，including one cerebral mala and three complicated with blackwater fever，at the dosage of 80mg／d im for 5 d(initial loading dose was doubled)，the clinical cure rate attained to 100%.The mean defervescence time was 37±24h，and the mean parasitenia clearance time was 47±20h.However there was a recurrence rate of 13% within 35d. Another 20 patients were treated with artesunate as control, at the dosage of 60 mg/d, iv, for 4 d (initial loading dose was doubled). Artesunate was similar to artemether in clinincal effect.

Key world: Plasmodium falciparum, artemether/therapeutic use, artesunate / therapeutic use

 

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