云南省疟疾防治研究所  车立刚  黄开国  董  莹  杨恒林  杨品芳

全文发表于《中国寄生虫病防治杂志》1990年第3卷第1期24-26页

  

提要：磷酸咯萘啶1.2g、磺胺多辛1.5g，伯喹67.5mg伍用；磷酸咯萘啶0.8g与磺胺多辛乙氨嘧啶复合片伍用，在抗氯喹恶性疟流行区分别治疗恶性疟34例和32例，治后平均退热时间分别为35.5±19.1h、37.3±17.6h，平均疟原虫无性体转阴时间为58±15.3h、59.8±18.9h，一个月内复燃率为6.5％、13.3％。前者清除配子体时间为5.4±3.7d，服药后配子体出现率17.4％，并能阻止恶性疟原虫在蚊体内的有性繁殖。后者无此作用。

关键词：抗氯喹恶性疟，咯萘啶

EFFICACY OF TWO COMBINED THERAPIES FOR TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA

Che Ligang, Huang Kaiguo, Dong Ying, Yang Hengli, Yang Pinfang

Yunnan Provincial Institute for Malaria Control

 

ABSTRACT.  Thirty-four cases with falciparum malaria were treated jointly with pyronaridine phosphate(1.2g base)，sulfadoxine(1.5g base) and primaquine(67.5mg base) in 3 days in the chloroquine-resistant areas of Mengla and Jinghong Counties，Yunnan province. While another group of 32 cases were treated combinedly with pyronaridine phosphate malaridine (0.8g), sulfadoxine(1.0g) and pyrimethamine(50mg) in 2 days. The average defervescent time of the 2 combined therapies were 35.5±19.1h and 37.3±17.6h；the mean asexual parasite clearance time 58±15.3h  and 50.±18.9h respectively.The recrudescence rate of the 2 groups were found to be 6.5％ and 13.3％after a follow-up of one month. With the former combined therapy，the gametocyte-clearance time was 5.4±3.7d，the sexual reproductions of the parasites in Anopheles mosquitos were restrained，which was not found when the later therapy was used. No noticeable side effects were observed in both therapies.

 

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