车立刚  黄开国  杨恒林  余  蕾  林志良  黄  荣    云南省疟疾防治研究所

全文发表于《中国寄生虫学与寄生虫病杂志》1987年第5卷第3期194-196页

 

提要: 将磷酸咯萘啶1.2g与磺胺多辛1.0g、伯喹45mg伍用，在抗氯喹恶性疟流行区治疗恶性疟48例，治疗后平均退热时间32±16h，平均原虫无性体转阴时间59±20.8h。服药后48h疟原虫无性体下降率为88～100％，即时疗效与单用磷酸咯萘啶1.2g对照组相似。伍用组一个月内复燃率2.5％，服药后配子体转阴时间1～12d，并能减少配子体出现，根治效果和配子体的作用优于单用组。三药伍用后毒副反应无明显增加，是治疗抗氯喹恶性疟的较好方案。

 

COMBINED USE OF PYRONARIDINE, SULFADOXINE AND PRIMAQUINE IN AREAS WITH CHLOROQUINE-RESISTANT FALCIPARUM MALARIA

Che Ligang, Huang Kaiguo, Yang Henglin, Yu Lei, Lin Zhiliang, Huang Rong

Institute of Malaria Control and Research, Yunnan

 

ABSTRACT.  Fourty-eight falciparum malaria cases were treated by pyronaridine phosphate (1.2gbase)jointly with sulfadimoxine(1g)and primaquine phosphate(45 mg base)in 2 days in Mengla County，Yunnan province，where chloroquine-resistant Plasmodium falciparum is endemic.36 falciparum malaria cases were treated with pyronaridine (1.2g)alone.The average defervescence time of the combined treatment group and the pyronaridine grcup was 32±16 h and 32.7±16h；the mean asezual parasite clearance time of the groups was 59±20.8 h and 64±22.9 h respectively.During 1 month follow-up，the asexual parasite recrudescence rate of the 2 groups was 2.5％ and 15.2％；the gametocyte-carrying rate was 50.0％（19／38）and 93.9％（31／33）.NO marked side effects were observed in the combined therapy.

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