云南省疟疾防治研究所  车立刚  陈文才  杨恒林  黄开国

全文发表于《中华流行病学杂志》1986年第7卷第2期88-91页

摘要: 采用WHO推荐的体外微量测定法和临床观察法，调查云南恶性疟抗氯喹株地理分布，证实云南省西南边境一线，恶性疟对氯喹的抗性程度很高，抗性率在96.0％以上，Ⅱ、Ⅲ级抗性在半数以上，半数有效量在6.9微克分子／孔以上；滇中地区抗性程度低，临床观察未发现抗性病例，体外测定半数有效量为2.55微克分子／孔；边境与滇中地区之间的地带，抗性程度居于两地区之间。

Investigation report on geographical distribution of chologoquine resistance of falciparum malaria in Yunnan

Che Ligang Chen Wencai Yang Henglin Huang Kaiguo

ABSTRACT.  By means of  Micro-determination in Vitro recommended by  WHO and Clinical obaervation,an investigation of the geographical distribution of drug (Chloroquinine)-resistant strains of  P.falciparum in Yunnan Province was made.It was revealed that in the south-west of Yunnan boarder-line，the resistance of malignant malaria to Chloro quinine therapy was very high，the incidence was higher than 96％，Ⅱ￡Ⅲ degrees being higher than 50%.50% effective dose is over 6.9mgmol／hole；In the Central Area of Yunnan，the degree of drug resistance was low.No drug -resistant clinical case was revealed.50%Effective dose determined in vitro was found to be 2.55ng／hole.The median District between the boarder-line and that of Central Yunnan，the degree of drug Resistance being the median range of the above two levels.